Neonatal Capsaicin Treatment (NCT) Downregulates Macrophage Metalloproteinase (MMP‐12) Likely via Reducing Substance P (SP) and Neurokinin A Receptor (NK1R) in the Lungs and Bronchoalveolar Lavage (BAL) Cells of Mice
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چکیده
منابع مشابه
Metalloelastase in lungs and alveolar macrophages is modulated by extracellular substance P in mice.
Metalloelastase (MMP-12), mainly produced by macrophages, has been shown to play a key role in the pathogenesis of emphysema in animal models. Chronic cigarette smoke increases pulmonary MMP-12, which is closely correlated with an elevation of pulmonary substance P (SP). Because alveolar macrophages (AMs) contain the neurokinin-1 receptor (NK1R), we tested whether SP was able to trigger the upr...
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Background and Aim: Despite therapeutic improvements in recent decades, multiple myeloma (MM) still remains as one of the leading causes of death all over the world. Previous studies have indicated role of neurokinin-1 receptor (NK1R) in the pathogenesis of cancer. Therefore, we decided to evaluate cytotoxic and apoptotic effects of aprepitant (NK1R antagonist) on MM-derived KMM-1 cell line. Ma...
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چکیده ندارد.
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2007
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.21.5.a408-b